The Spinola Castle of Sesto Campano is mentioned for the first time in a document in 1064 on the occasion of the donation by Count Paldone of Venafro to Abbot Desiderio.
The construction of the Castle  dates back to the Longobard period. It was built by King Arerchi in the 10th century but it was modified in the 17th century. In 1465 King Ferrante I of Aragon granted Sesto as a feud to Diomede Carafa of the Stadera who in 1569 sold the castle to Isabella of Lannoy, wife of Philip of Lannoy, prince of Sulmona and count of Venafro. His son Orazio sold Sesto to Filippo Spinola  (1536-1584) in 1582.